Cr, Protein Restriction

[jay kaye]

viewtopic.php?f=22&t=49526

Jeff and Jim,

Was anything said about the recent research that postulates that it is not so much the CR but the resulting protein restriction, primarily the amino acid Methionine consumption.

Same question but by "upregulating dehydroepiandrosterone (DHEA)".

Both are reduced by just this WOE.

J

[JeffN]

I address the issue of protein restriction here...

viewtopic.php?f=22&t=46789&p=482217p482217#p482217

I would also recommend the links in that thread too

In Health
Jeff

[jay kaye]

Jeff,

Did you move this? I meant this as a reply in the thread viewtopic.php?f=22&t=49526

Some for links in the post you cite are broken. The one to the Methuselah foundation re Methionine consumption links to a new unsearchable site.

Some of the most recent papers seem to say that is the really only the protein restricting portion of CR that is most important. Is Dr. Fontana moving in that direction? I know at one time he did not feel it was as important as overall CR/IF/

http://www.sciencedirect.com/science/ar ... 7414015256

http://www.ncbi.nlm.nih.gov/pubmed/26278039

Thanks,
j

[JeffN]

Jeff,

Did you move this? I meant this as a reply in the thread viewtopic.php?f=22&t=49526

Only the OP and I can post in a thread. To post a question, start a new thread.

Thanks

Some for links in the post you cite are broken. The one to the Methuselah foundation re Methionine consumption links to a new unsearchable site.

Some of the most recent papers seem to say that is the really only the protein restricting portion of CR that is most important. Is Dr. Fontana moving in that direction? I know at one time he did not feel it was as important as overall CR/IF/

http://www.sciencedirect.com/science/ar ... 7414015256

http://www.ncbi.nlm.nih.gov/pubmed/26278039

Thanks,
j

Some of the linked website were updated and I have to update the links which I will do after the 10-Day

However,Dr Fontana is recommending the RDA for protein of .8gm/kg. When he refers to the protein restricted diets, he is discussing diets that are at the RDA and not further restricted.

http://www.thefutureofscience.org/uploa ... 923659.pdf

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673798/

https://medicine.wustl.edu/news/headlin ... te-cancer/

And, for a long read, where you can read Michael Rae's analysis...

http://www.longecity.org/forum/topic/41 ... ntry428539

" Note that the methionine post linked above was heavy on emphasizing the limitations of the methionine restriction research at that time; today, I find it pretty convincing -- just irrelevant for human application, whereas methionine moderation is justified practice. (Please, please, please, people, stop muddying the water by referring to limiting one's intake of some nutrient to RDAish levels as "restriction" of that nutrient! "

This is the level that Fontana, Rae and several other of the CR leaders are practicing and recommending.

For a while in CR, methionine restriction became very popular and as potentially being even more powerful than CR alone. However, at the end of the day, after its all been evaluated, it turns out methionine restriction is really about methionine moderation. And, if you are following a healthy predominately plant based diet as we recommend, then you are at the .8gm/kg IBW. So, the problem was not methionine restriction per see but methionine excess in the SAD eaters and heavy animal protein/products eater.

In Health
Jeff

[jay kaye]

I read the long one by Michael Rae.

I note with interest slide 20, It seems that the CR human model they use was not very restrictive in calories, only about 10% less than the vegan. What I am surprised by is the very high fat, 42% by calories used by the vegans. Even the CR group was high at fat 28%. The protein in the CR group as also what I would consider very high at 28%.

So with the fat% and protein% being so much low on this WOE, how does that factor into his thinking on longevity. Is this just because he is basing his conclusions using CR vs SAD or regular high fat Vegan?

Does he factor in people on this WOE in his conclusions? (Or is he moving in that direction with his new study?)

From the totality of what I read I conclude that the WOE, a very very low fat and low protein are the major cause of the longevity, not the apparently minimal amount of CR energy restriction. Or am I missing something?

I find the whole subject fascinating. I appreciate your time I addressing my questions especially since I feel like I may be making wild conclusions.

j

J

[JeffN]

I would recommend reading this thread

viewtopic.php?f=22&t=40765&p=419022

In Health
Jeff