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Common Health Problems: Gallbladder Disease

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Understanding the cause of gallbladder disease will help you with preventing or treating it. More than 90% of gallstones found in people living in affluent nations are composed primarily of cholesterol. When the bile fluids in the gallbladder become over-saturated with cholesterol, precipitation of the cholesterol into solid crystals begins, and then gradually accumulate to form stones of variable sizes. A diet high in cholesterol-containing foods–red meats, poultry, fish, and dairy products–is the primary culprit for the development of the super saturated levels of cholesterol in the bile. Polyunsaturated oils (vegetable oils), too, will cause the liver to excrete larger quantities of cholesterol that pass into the fluids in the gallbladder, and thereby favor stone formation.

Avoid surgery whenever possible. Several recent studies have addressed the issue of whether or not asymptomatic gallstones should be removed. The findings consistently show that your risk of dying and/or developing complications is much greater if you choose to have surgery than if you decide to leave the stones alone.

People suffering pain from gallbladder disease are most likely to visit hospital operating suites. If, however, they are not too ill, they still have a very good chance of avoiding the surgeon’s knife by making the sensible decision to stop eating the high-fat, high-cholesterol foods that provoke the formation of gallstones. A low-fat diet is the time-honored approach for relieving gallbladder pain and preventing further attacks. However, changing the diet does not guarantee that the gallstones will dissolve; and the disappearance of stones should not be your goal.

Well-meaning doctors will sometimes frighten patients into accepting surgery by emphasizing the possibility of developing cancer of the gallbladder from the constant irritation produced by the gallstones. Actually the risk of cancer from this cause is insignificant. Don’t be fooled into submitting to the surgeon’s knife for the removal of Asymptomatic gallstones because of a doctor-induced cancer phobia.

The idea that gallstones will slip into the duct and get caught there is another excuse given to patients to justify the need to operate on their “silent” Asymptomatic gallstones. Actually, very rarely do small stones, even those that are being dissolved away through the use of drugs, become trapped in the duct to block it.

If you have gallstones, then alter your diet today. If this approach for one reason or another is not successful (after you’ve given it a trial for a reasonable time), you will have no trouble in finding an experienced surgeon to take out your gallbladder. Each year an estimated 515,000 patients in the United States have this operation, at an average cost of $10,000 per operation.


  • Recommendations
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    A no-cholesterol, low-fat diet (including all vegetable fats too), for preventing gallbladder disease and gallstones. If you develop pain see your doctor. If the attack subsides and your situation is not a surgical emergency, then eat a very low-fat diet to avoid further attacks. Do not allow an operation to remove gallstones that do not cause symptoms.


  • References
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    Finlayson, N. Cholecystectomy for gallstones. A good thing if they cause symptoms. Br Med J 298:133, 1989

    Bateson, M. Gallstone disease–present and future. Lancet 2:1265, 1986

    Editorial–Cholecystectomy: the dissatisfied customer. Lancet 1:339, 1988

    Bilhartz, L. Cholesterol gallstone disease: the current status of nonsurgical therapy. Am J Med Sci 296:45, 1988

    Thistle, J. The natural history of cholelithiasis: The National Cooperative Gallstone Study. Ann Intern Med 101:171, 1984

    Pixley, F. Dietary factors in the aetiology of gall stones: a case control study. Gut 29:1511, 1988

    Pixley, F. Effect of vegetarianism on development of gall stones in women. Br Med J 291:11, 1985

    Wechsler, J. Influence of increased fibre intake on biliary lipids. Scand J Gastroenterol-Suppl 129:185, 1987

    DenBesten, L. The effect of dietary cholesterol on the composition of human bile. Surgery 73:266, 1973

    Hepner, G. Altered bile acid metabolism in vegetarians. Dig Dis 20:935, 1975

    Friedman, L. Management of asymptomatic gallstones in the diabetic patient. A decision analysis. Ann Intern Med 109:913, 1988

    Ransohoff, D. Prophylactic cholecystectomy or expectant management for silent gallstones. A decision analysis to assess survival. Ann Intern Med 99:199, 1983

    Maringhini, A. Gallstones, gallbladder cancer, and other gastrointestinal malignancies. Ann Intern Med 107:30, 1987

    Linos, D. Cholecystectomy and carcinoma of the colon. Lancet 2:379, 1981




  1. John says:
    I have a problem in my left lower leg in that the valves in the veins are not working. I have been on te MacDougall diet for 4 years and my cholesterol liver and kidneys are all good just the leg. My diet is 1 cup of rice sweetened with banana and grapes and homemade oat milk = breaky Lunch 2potatos sweet potato and veg Tea = 2slices of homemade bread with beans and tomato. I find this a good diet + corn cobs for a snack. I am on my own and 84 years of age. last time I wrote to the Doc and Mary he was alive and well and it was a shock and sadness when he died like I had lost a good friend yours sincerely John Wills. .
    1. Admin
      Heather McDougall says:
      Hi John, Thank you so much for your kind message. I’m really glad you shared this, and I know my parents would have appreciated hearing from you. It sounds like you’ve done a wonderful job taking care of your health over the years. Your diet is simple, consistent, and very much in line with what we recommend. What you’re describing with the valves in the veins is usually more of a circulation issue rather than something diet alone can correct. Good nutrition absolutely supports overall vascular health, but this is something best managed with your doctor. Simple things like regular walking, elevating your legs when you can, and sometimes compression stockings can help. I hope that helps.
  2. Stefano Piviali says:
    In early 2009, I was diagnosed with Rheumatoid Arthritis — crippled and in severe pain. Living in Australia and unable to travel to the USA, I reached out to Dr. John, who responded with extraordinary kindness. Through his supportive emails and guidance, I followed the McDougall diet and within 6–8 months I was free of RA. His selflessness left a lasting impression on me, and I have recommended the McDougall program to everyone who would listen ever since. Unfortunately, in 2011 I had my gallbladder removed, and despite maintaining a whole food plant-based diet, I have struggled with chronic diarrhoea ever since. This has left me underweight and frequently dehydrated, and has caused considerable disruption to my daily life. Over the years I tried various medications to manage the diarrhoea, but without lasting success — largely because I am reluctant to rely on pharmaceutical solutions long-term. Three months ago, however, my GP made clear that getting the diarrhoea under control was essential to rebuilding my weight and muscle mass. I began taking Loperamide three times daily and have seen good results. At 72, I exercise every day and am steadily gaining muscle. That said, I remain concerned about the potential long-term side effects of Loperamide, and I find myself wondering whether a dietary adjustment might allow me to manage this condition without ongoing medication. I was deeply saddened by Dr. John's passing, but I take great comfort in knowing that his life's work continues to help so many people around the world.
    1. Admin
      Heather McDougall says:
      Thank you so much for sharing your story. What an incredible journey, and such a powerful example of how this way of eating can change a life. I know my dad would have really appreciated hearing this. What you’re experiencing after gallbladder removal is something we do see. Without a gallbladder, fat can be harder to tolerate and can contribute to ongoing digestive distress. Keeping fat as low as possible often helps, which means leaning into very simple, starch-based meals. As you do that, you may need to eat more overall to meet your energy needs, especially since you’re working on regaining weight and muscle. In terms of the medication, it sounds like you are seeing real benefits. There is always a balance to consider. While it’s understandable to want to avoid long-term use, improving your digestion and maintaining your strength right now are important wins. You can continue to adjust your diet alongside this and see how your body responds over time. I’m really glad you shared this.

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