Some comments...
1) The vitamin D craze is passing and much of the hype around how much to take and what levels are optimal, has proven to be way overblown
Vitamin D: More may not be better
http://jcem.endojournals.org/content/ea ... 5.abstract"Vitamin D in the 20–36 ng/ml range was associated with the lowest risk for mortality and morbidity. The hazard ratio below and above this range increases significantly."2) The recent RCT”s have shown no benefit and the USPSTF changed their recommendations
https://www.uspreventiveservicestaskfor ... medication3) I don’t think we should be doing much, if any, vitamin D testing unless someone is high risk
viewtopic.php?f=22&t=100554) The acceptable level are much lower then being recommended
Vitamin D Deficiency — Is There Really a Pandemic?
NEJM 375;19 nejm.org November 10, 2016
http://www.nejm.org.sci-hub.cc/doi/pdf/ ... JMp1608005"A common misconception is that the RDA functions as a “cut point” and that nearly the entire population must have a serum 25(OH)D level above 20 ng per milliliter to achieve good bone health. The reality is that the majority (about 97.5%) if the population has a requirement of 20 ng per milliliter or less. Moreover, by definition of an average requirement, approximately half the population has a requirement of 16 ng per milliliter (the EAR) or less. . These concepts are depicted in the population reference-value distribution shown in Panel A, which highlights the relationship between the EAR and the RDA.
Vitamin D: What’s the “right” level?
Monique Tello, MD, MPH
JANUARY 06, 2017 (Updated)
http://www.health.harvard.edu/blog/vita ... 6121910893“For perimenopausal women or other groups of people with higher fracture risk, certainly a level of 20 or above is ideal,” and he adds: “For the vast majority of healthy individuals, levels much lower, 15, maybe 10, are probably perfectly fine, and so I would say I agree with what the authors of the New England Journal perspective article are saying.”Serum 25-hydroxyvitamin D level, chronic diseases and all-cause mortality in a population-based prospective cohort: the HUNT Study, Norway.
Sun YQ, Langhammer A, Skorpen F, Chen Y, Mai XM.
BMJ Open. 2017 Jul 3;7(6):e017256. doi: 10.1136/bmjopen-2017-017256.
PMID: 28674149 Free Article
http://bmjopen.bmj.com/content/7/6/e017256.longIt appears that the risk of dying flat lines above 15 to 16 ng/ml. The HR increases quite a bit once you get below 12 ng/ml. A level of 20ng/ml does not appear to be associated with any significant increased risk of dying from all causes. Up to 44ng/ml doesn't seem to be associated with any significant impact on the overall risk of dying. From this, it looks like 20 to 44ng/ml could be considered the normal range. Anything below 20ng/ml may be insufficient for some and anything below 12 to 15ng/ml appears to be associated with an increased risk of dying as many people maybe deficient.I think anything from around 15- 20, up to 30- 35 is fine. I don’t recommend anything higher unless it occurs naturally from the sun. If someone is under 15, I would recommend first a trial with adequate sunshine, then if needed, add in foods with Vitamin D (Mushrooms), then if needed, artificial UV light. This is usually more then enough to achieve these levels.
I can link you to my full discussion on this, especially the last few years where most of this comes from.
Hope this helps
Jeff