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Jubilee wrote:The nurse is wrong about the ratio thing. Keep in mind the results of the Framingham nurses study. That study kept track of a bunch of people and among other things, correlated their heart issues with their cholesterol over many years. (Maybe someone can give a link or more specific numbers). Anyhow, the number I remember very well is how many people who had TC of 150 or less had heart attacks. The answer? ZERO!!! Never mind their ratios- it's TC that is the best predictor of heart health.
KIRK HAMILTON: Now how about if somebody let's say was on a very strict no-fat, let=s say vegan diet. And let's say for example the Tarahumara Indians have very low cholesterols but they have very low HDLs as well and so they have a high cholesterol/HDL ratio but they don't have atherosclerosis. Does it get less-
DR. WILLIAM CASTELLI: Well if they have a low enough LDL, see I get sent people that have a 10 HDL and a 4 HDL and you'll never be able to get their ratios down. But then I take your LDLs under 70 and your triglycerides under 60 and now you don't need HDL. It was actually Michael Brown of Dallas there with Goldstein, one of the Nobel laureate folks, he used to say if your LDL was under 90 or 80 you didn't need HDL. Well I don't think that's true but if you're a lot lower than that, you probably don't need HDL. The idea was your cells were not making more cholesterol than they could use, so you didn't need HDL to take away the excess because if they make more than they can use, they make a fat deposit in the cell of cholesterol and if it's a cell that's in your artery wall you get the atherosclerosis. We need to get those triglycerides down to get rid of the atherogenicity of these particles and at the same time improve the nature of the LDLs and the HDLs.
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