Association of Proton Pump Inhibitors With Risk of Dementia

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Association of Proton Pump Inhibitors With Risk of Dementia

Postby jay kaye » Tue Feb 16, 2016 1:38 pm

Association of Proton Pump Inhibitors With Risk of Dementia

http://archneur.jamanetwork.com/article ... id=2487379

" Proton pump inhibitors (PPIs) are widely used for the treatment of gastrointestinal diseases but have also been shown to be potentially involved in cognitive decline."

"Results A total of 73 679 participants 75 years of age or older and free of dementia at baseline were analyzed. The patients receiving regular PPI medication (n = 2950; mean [SD] age, 83.8 [5.4] years; 77.9% female) had a significantly increased risk of incident dementia compared with the patients not receiving PPI medication (n = 70 729; mean [SD] age, 83.0 [5.6] years; 73.6% female) (hazard ratio, 1.44 [95% CI, 1.36-1.52]; P < .001)."

Another great benefit of the WOE, getting off Reflux (GERD) prescriptions

J
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