You must pour oil on your salad!?!?
Posted: Wed Jun 20, 2012 9:17 am
Yeah - fat helps the absorption, but how much fat?
http://www.sciencedaily.com/releases/20 ... an+Diet%29
http://www.sciencedaily.com/releases/20 ... an+Diet%29
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Leif Varmark wrote:Yeah - fat helps the absorption, but how much fat?
http://www.sciencedaily.com/releases/20 ... an+Diet%29
John McDougall wrote:
If you want to believe that there is a health advantage from more nutrients entering your body, then at least act conservatively. For maximum carotenoid absorption the amount of fat required is as little as 1/7th of an avocado—about a tablespoonful per meal. Also heating and blending fruits and vegetables enhance nutrient absorption3—and these are much safer approaches than stuffing your overweight self with fat.
Objective
To investigate the mechanisms underlying the satiety-promoting effects of a novel protease inhibitors concentrate derived from potato (PPIC).
Methods
Acute and prolonged effects of oral PPIC administration (100 mg/kg per day) on food intake, body weight, and gastric emptying were evaluated in healthy rats. Parameters of body weight, food intake, plasma glucose, insulin, and cholecystokinin (CCK) were measured. Duodenal proteolytic activity and CCK expression were determined in tissue extracts. Intestinal STC-1 cell culture model was used to investigate the direct effect of PPIC on CCK transcript level and secretion.
Results
Acute oral administration of PPIC reduced immediate food intake during the first two hours following the treatment, delayed gastric emptying, and decreased proteolytic activity in the duodenum. Repeated oral ingestion of PPIC reduced weight gain in male rats and significantly elevated the plasma CCK levels. Although duodenal mucosal CCK mRNA levels increased in response to PPIC administration, the concentrate failed to elevate CCK expression or release in STC-1 cells. The 14-day ascending dose range study (33 to 266 mg/kg PPIC per day) showed no adverse side effects associated with PPIC administration.
Conclusion
These findings provided evidence that PPIC is effective in reducing food intake and body weight gain in healthy rats when administered orally by increasing circulating CCK levels through a trypsin-dependent mechanism.